ADME-Tox in drug discovery: integration of experimental and computational technologies

Knowledge Source Identification
Knowledge source name	ADME-Tox in drug discovery: integration of experimental and computational technologies
Owner/Developer	Drug Discovery Today
Country	Netherlands
Languages	English
URL	http://www.sciencedirect.com/science/article/pii/S1359644603028289
Description	Over the past ten years, in vitro experimental tools to characterize ADME-Tox profiles of compounds have been applied in early stages of the drug discovery process to increase the success rate of discovery programmes and to progress better candidates into drug development. Application of in silico ADME-Tox models has further enhanced discovery support, enabling virtual screening of compounds and thus, application of ADME-Tox at every stage of the discovery process. Ultimately, effective and efficient ADME-Tox support of discovery will depend on a complementary and synergistic use of experimental and in silico ADME-Tox.
Knowledge Source Category
Category	Publication
Sub categories	Review / Research article
Knowledge Dissemination and Sharing
Dissemination channel	Website, Printed
Targeted audience (specified/objective analysis)	Researchers, Scientists, Industry
Users access	Restricted access
Knowledge Characterization
3Rs relevance	Replacement, Reduction
Purpose	Method development, Documentation and information
Technology/Tools	Alternative test methods (in vitro), Non-testing methods (in silico)