3D printing of PLGA scaffolds for tissue engineering

Knowledge Source Identification
Knowledge source name 3D printing of PLGA scaffolds for tissue engineering
Owner/Developer Biomedical Materials Research
Country United States of America
Languages English
URL http://onlinelibrary.wiley.com/wol1/doi/10.1002/jbm.a.35871/full
Description We proposed a novel method of generation of bioresorbable polymeric scaffolds with specified architectonics for tissue engineering using extrusion three-dimensional (3D) printing with solutions of polylactoglycolide in tetraglycol with their subsequent solidifying in aqueous medium. On the basis of 3D computer models, we obtained the matrix structures with interconnected system of pores ranging in size from 0.5 to 500 µm. The results of in vitro studies using cultures of line NIH 3Т3 mouse fibroblasts, floating islet cultures of newborn rabbit pancreas, and mesenchymal stem cells of human adipose tissue demonstrated the absence of cytotoxicity and good adhesive properties of scaffolds in regard to the cell cultures chosen.
Knowledge Source Category
Category Publication
Sub categories Protocol
Knowledge Dissemination and Sharing
Dissemination channel Website
Targeted audience (specified/objective analysis) Scientists, Students, Industry, Researchers
Users access Fee-based access
Knowledge Characterization
3Rs relevance Replacement
Purpose Method development, Documentation and information
Technology/Tools 3D printing, Tissue engineering