Transgenic Mouse Models Transferred into the Test Tube: New Perspectives for Developmental Toxicity Testing In Vitro?

Knowledge Source Identification
Knowledge source name	Transgenic Mouse Models Transferred into the Test Tube: New Perspectives for Developmental Toxicity Testing In Vitro?
Owner/Developer	Trends in Pharmacological Sciences
Country	Netherlands
Languages	English
URL	http://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(16)30076-1
Description	Despite our increasing understanding of molecular mechanisms controlling embryogenesis, the identification and characterization of teratogenic substances still heavily relies on animal testing. Embryonic development depends on cell-autonomous and non-autonomous processes including spatiotemporally regulated extracellular signaling activities. These have been elucidated in transgenic mouse models harboring easily detectable reporter genes under the control of evolutionarily conserved signaling cascades. We propose combining these transgenic mouse models and cells derived thereof with existing alternative toxicological testing strategies. This would enable the plausibility of in vitro data to be verified in light of in vivo data and, ultimately, facilitate regulatory acceptance of in vitro test methods.
Knowledge Source Category
Category	Publication
Sub categories	Press release
Knowledge Dissemination and Sharing
Dissemination channel	Website
Targeted audience (specified/objective analysis)	Scientists, Industry, Researchers
Users access	Open access
Knowledge Characterization
3Rs relevance	Replacement
Purpose	Fundamental studies, Documentation and information
Technology/Tools	Alternative test methods (in vitro), Animal testing (in vivo), Stem cells