Stem Cell-Derived Systems in Toxicology Assessment

Knowledge Source Identification
Knowledge source name Stem Cell-Derived Systems in Toxicology Assessment
Owner/Developer Stem Cells and Development
Country United States of America
Languages English
Description Industrial sectors perform toxicological assessments of their potential products to ensure human safety and to fulfill regulatory requirements. These assessments often involve animal testing, but ethical, cost, and time concerns, together with a ban on it in specific sectors, make appropriate in vitro systems indispensable in toxicology. In this study, we summarize the outcome of an EPAA (European Partnership of Alternatives to Animal Testing)-organized workshop on the use of stem cell-derived (SCD) systems in toxicology, with a focus on industrial applications. [...] The future of SCD toxicological tests will combine advanced cell culture technologies and biokinetic measurements to support regulatory and research applications. However, scientific and technical hurdles must be overcome before SCD in vitro methods undergo appropriate validation and become accepted in the regulatory arena.
Knowledge Source Category
Category Publication
Sub categories Review / Research article
Knowledge Dissemination and Sharing
Dissemination channel Website
Targeted audience (specified/objective analysis) Scientists, Industry, Researchers
Users access Open access
Knowledge Characterization
3Rs relevance Replacement
Purpose Method development, Documentation and information
Technology/Tools Alternative test methods (in vitro), Stem cells