||CELPHEDIA (Creation, Breeding, Phenotyping, Distribution and Archiving of model organisms) mainly aims to develop innovative, standardized and massively parallel technological approaches, in order to accelerate the understanding of the genome and the generation of human or animal disease models. CELPHEDIA is a network including fifteen centers spread throughout the French territory to be closer to the users. This distributed operational RI (Research Infrastructure) gathers a remarkable palette of expertise, skills and knowledge unique in Europe, in the domains of creation, functional exploration, archiving and distribution of organisms, used as models for fundamental research and preclinical approaches: rodents with the mouse as a leader, non-human primates and non mammalians including aquatic vertebrates. The goal is to enable the centers to coordinate their scientific activities and to pool all or part of their means. The geographical breakdown of the centers in France and the spread of big families of organism models, provides a better support for research to address different needs, such as enhanced security and sanitary constraints, limited use of animals and improvement of animal welfare.