Acute Toxicity Testing Without Animals
| Knowledge Source Identification | |
|---|---|
| Knowledge source name | Acute Toxicity Testing Without Animals |
| Owner/Developer | European Coalition to End Animal Experiments |
| Abbreviated owner | ECEAE |
| Country | United Kingdom |
| Languages | English |
| URL | http://www.eceae.org/_lib/userfiles/files/Downloads/AcuteToxicityTestingWithoutAnimals_ECEAE_2005.pdf |
| Contact email | info@eceae.org |
| Description | Since the early days of the REACH proposals, it has been accepted by all parties that the numbers of animals used to gain toxicity information on chemicals should be kept to an absolute minimum. In this report, we argue specifically that acute toxicity data should not be sought from animal tests. The underlying principle of such tests on rats and mice is that the results can be effectively extrapolated to humans. In fact, after nearly 80 years of use of these tests, the predictivity of rodent data for human acute toxic effects has been disputed but never proven. |
| Knowledge Source Category | |
| Category | Publication |
| Sub categories | Report |
| Knowledge Dissemination and Sharing | |
| Dissemination channel | Website |
| Targeted audience (specified/objective analysis) | Scientists, Policy-makers, Regulators, Industry |
| Users access | Open access |
| Knowledge Characterization | |
| 3Rs relevance | Replacement |
| Purpose | Documentation and information |
| Legislative framework | REACH Regulation (EC) No 1907/2006 |