Acute Toxicity Testing Without Animals

Knowledge Source Identification
Knowledge source name Acute Toxicity Testing Without Animals
Owner/Developer European Coalition to End Animal Experiments
Abbreviated owner ECEAE
Country United Kingdom
Languages English
Contact email
Description Since the early days of the REACH proposals, it has been accepted by all parties that the numbers of animals used to gain toxicity information on chemicals should be kept to an absolute minimum. In this report, we argue specifically that acute toxicity data should not be sought from animal tests. The underlying principle of such tests on rats and mice is that the results can be effectively extrapolated to humans. In fact, after nearly 80 years of use of these tests, the predictivity of rodent data for human acute toxic effects has been disputed but never proven.
Knowledge Source Category
Category Publication
Sub categories Report
Knowledge Dissemination and Sharing
Dissemination channel Website
Targeted audience (specified/objective analysis) Scientists, Policy-makers, Regulators, Industry
Users access Open access
Knowledge Characterization
3Rs relevance Replacement
Purpose Documentation and information
Legislative framework REACH Regulation (EC) No 1907/2006