Opportunities for reducing the use of non-human primates in the development of monoclonal antibodies – a workshop report

Knowledge Source Identification
Knowledge source name	Opportunities for reducing the use of non-human primates in the development of monoclonal antibodies – a workshop report
Owner/Developer	National Center for Replacement, Refinement & Reduction of Animals in Research
Abbreviated owner	NC3Rs
Country	United Kingdom
Languages	English
URL	https://www.nc3rs.org.uk/sites/default/files/documents/Workshop_reports/Opportunities_for_reducing_the_use_of_non-human_primates_in_the_development_of_monoclonal_antibodies_%28Workshop_report%29.pdf
Description	The workshop provided a forum for open and frank discussion about the possibility of replacing or reducing primate use in the development of monoclonal antibodies (MAbs). There was general consensus that there are opportunities for reduction by the use of transgenic rodents and/or surrogate antibodies and replacement by the use of in vitro data and humans as the toxicology species. There are major challenges if these alternatives are to be realised in practice and accepted by regulatory bodies.
Knowledge Source Category
Category	Publication
Sub categories	Report
Knowledge Dissemination and Sharing
Dissemination channel	Website
Targeted audience (specified/objective analysis)	Scientists, Regulators, Industry
Users access	Open access
Knowledge Characterization
3Rs relevance	Reduction
Purpose	Animal welfare, Method development
Technology/Tools	Alternative test methods (in vitro), Animal testing (in vivo)