Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing

Knowledge Source Identification
Knowledge source name Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing
Owner/Developer SEURAT-1
Country Belgium
Languages English
Description The SEURAT-1 research initiative will publish a series of six Annual Reports. These Annual Reports provide a comprehensive overview about developments ultimately targeting the replacement of animal tests in the field of repeated dose systemic toxicity assessment. These books called "Towards the replacement of in vivo repeated dose systemic toxicity testing", aim to inform policy makers about scientific progress relevant to the implementation of European Directives and Regulations and about essential gaps in knowledge corresponding to research needs.
Knowledge Source Category
Category Publication
Sub categories Book / Textbook, Report
Knowledge Dissemination and Sharing
Dissemination channel Website, Printed
Targeted audience (specified/objective analysis) Scientists, Regulators, Industry, Researchers
Users access Open access
Knowledge Characterization
3Rs relevance Replacement
Purpose Method development, Documentation and information, Regulatory testing, Toxicological and safety evaluation
Legislative framework Cosmetics Regulation (EC) No 1223/2009, REACH Regulation (EC) No 1907/2006, CLP Regulation (EC) No 1272/2008
Technology/Tools Alternative test methods (in vitro), Non-testing methods (in silico), Stem cells, Omics, Integrated approaches to testing and assessment (IATA), High throughput screening, High content screening, Analytics