Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures

Knowledge Source Identification
Knowledge source name	Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures
Abbreviated name	NOTOX
Owner/Developer	European Commission and Cosmetics Europe
Country	Germany
Languages	English
URL	http://www.notox-sb.eu/
Contact	http://notox-sb.eu/contact/
Description	NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D systems to generate own experimental data to develop and validate predictive mathematical and bioinformatic models characterizing long term toxicity responses.
Knowledge Source Category
Category	Research Program/Project/Grant
Sub categories	EU Program
Knowledge Dissemination and Sharing
Dissemination channel	Website, Audio / Video, Printed
Targeted audience (specified/objective analysis)	Scientists, Regulators, Industry, Researchers
Users access	Open access
Knowledge Characterization
3Rs relevance	Replacement
Purpose	Regulatory testing, Toxicological and safety evaluation, Method development
Technology/Tools	Alternative test methods (in vitro), Non-testing methods (in silico)