Stem cells for relevant efficient extended and normalized toxicology

Knowledge Source Identification
Knowledge source name Stem cells for relevant efficient extended and normalized toxicology
Abbreviated name SCR&Tox
Owner/Developer European Commission and Cosmetics Europe
Country France
Languages English
Description In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely and triggered to differentiate into any cell type. SCR&Tox aims at making use of these two attributes to provide in vitro assays for predicting toxicity of pharmaceutical compounds and cosmetic ingredients. The consortium has been designed to address all issues related with biological and technological resources to meet that goal.
Knowledge Source Category
Category Research Program/Project/Grant
Sub categories EU Program
Knowledge Dissemination and Sharing
Dissemination channel Face-to-face, Website, Social media, Printed
Targeted audience (specified/objective analysis) Scientists, Regulators, Industry, Researchers
Users access Open access
Knowledge Characterization
3Rs relevance Replacement
Purpose Regulatory testing, Toxicological and safety evaluation, Method development, Documentation and information
Technology/Tools Alternative test methods (in vitro), Stem cells