Adverse Outcome Pathway Knowledge Base

Knowledge Source Identification
Knowledge source name Adverse Outcome Pathway Knowledge Base
Abbreviated name AOP-KB
Owner/Developer The Organisation for Economic Co-operation and Development, European Commission, US Environmental Protection Agency, US Army Corps of Engineers - Engineering Research and Development Center
Abbreviated owner OECD, EC, US EPA, ERDC
Country France
Languages English
Description To enable the scientific community, in one central location, to share, develop and discuss their AOP related knowledge, the OECD has launched a project to develop the "Adverse Outcome Pathway Knowledge Base" (AOP-KB). The AOP-KB allows all stakeholders to build AOPs by entering and then linking information about MIEs, KEs, AOs and Chemical Initiators. Knowing that pathway elements are not necessarily unique to a single AOP, value is added to existing knowledge by facilitating the re-use of MIE, KE and AO information in multiple AOPs, which prevents redundancy and make the collective knowledge about those entities available in all AOPs in which they appear.
Knowledge Source Category
Category Information System
Sub categories Knowledge-base
Knowledge Dissemination and Sharing
Dissemination channel Website
Targeted audience (specified/objective analysis) Scientists
Users access Open access, User registration
Knowledge Characterization
3Rs relevance Replacement, Reduction
Purpose Fundamental studies, Toxicological and safety evaluation, Documentation and information