National Reference Laboratory for Experimental Toxicology

Knowledge Source Identification
Knowledge source name National Reference Laboratory for Experimental Toxicology
Owner/Developer The National Institute of Public Health
Country Czechia
Languages English
Contact email
Description NRL for Experimental Toxicology pursues research and reference activities and provides expert and consulting services. It is focused on testing of dermatotoxic, immunotoxic and phototoxic effects of dermotropic substances and materials, namely chemicals and preparations, cosmetics, medical devices and other products coming into contact with skin or mucous tissue. The Laboratory develops and implements alternative toxicological methods in vitro employing cell and tissue cultures in order to replace conventional animal testing in the field of local tolerance, dermal penetration, phototoxicity and immunotoxicity. It represents the leading methodological center for alternatives in the Czech Republic. The Laboratory evaluates specific functions of active and protective ingredients of consumer products by means of alternative methods in vitro, instrumental and clinical studies with the aim of public health protection and promotion. EU-NETVAL member.
Knowledge Source Category
Category Organization
Sub categories Consultancy, Governmental Organization, Services
Knowledge Dissemination and Sharing
Dissemination channel Website
Targeted audience (specified/objective analysis) Not specified
Knowledge Characterization
3Rs relevance Replacement, Reduction, Refinement
Purpose Toxicological and safety evaluation, Education and training, Documentation and information, Regulatory testing, Validation, Method development
Technology/Tools Alternative test methods (in vitro), Stem cells, Analytics