ISSTOX Chemical Toxicity Databases

Knowledge Source Identification
Knowledge source name ISSTOX Chemical Toxicity Databases
Owner/Developer Istituto Superiore di Sanita
Abbreviated owner ISS
Country Italy
Languages English, Italian
Contact Romualdo Benigni
Contact email
Description The ISSTOX databases are curated by the Istituto Superiore di Sanità, and contain experimental results relative to various types of chemical toxicity. The toxicity results have been critically reviewed. Beside being a repository of data, the databases have been specifically designed as an expert decision support tool. A characterizing feature is that the chemical structures are coded in such a way as to be directly usable for Structure-Activity Relationships studies. The use of experimental data for Structure-Activity Relationship studies amplifies their informative value (e.g., through toxicity predictions), and contributes to the reduction and replacement of animal experimentation. The structure of these databases is inspired by that of the Distributed Structure-Searchable Toxicity (DSSTox ) Network of the US Enviromental Protection Agency (US EPA). Similarly to the DSSTox spirit, this project wants to contribute to the free diffusion of scientific data in a standardized, easy to read format.
Knowledge Source Category
Category Information System
Sub categories Database
Knowledge Dissemination and Sharing
Dissemination channel Website
Targeted audience (specified/objective analysis) Not specified
Users access Open access
Knowledge Characterization
3Rs relevance Replacement, Reduction
Purpose Documentation and information
Technology/Tools Alternative test methods (in vitro), Animal testing (in vivo)