Alternative methods for regulatory toxicology – a state-of-the-art review

Knowledge Source Identification
Knowledge source name	Alternative methods for regulatory toxicology – a state-of-the-art review
Owner/Developer	European Commission, Joint Research Centre
Abbreviated owner	EC - JRC
Country	Italy
Languages	English
URL	https://echa.europa.eu/documents/10162/13634/echa_jrc_sla_report_en.pdf
Description	This state-of-the art review is based on the final report of a project carried out by the European Commission’s Joint Research Centre (JRC) for the European Chemicals Agency (ECHA). The aim of the project was to review the state of the science of non-standard methods that are available for assessing the toxicological and ecotoxicological properties of chemicals. Non-standard methods refer to alternatives to animal experiments, such as in vitro tests and computational models, as well as animal methods that are not covered by current regulatory guidelines. This report therefore reviews the current scientific status of non-standard methods for a range of human health and ecotoxicological endpoints, and provides a commentary on the mechanistic basis and regulatory applicability of these methods.
Knowledge Source Category
Category	Publication
Sub categories	Report
Knowledge Dissemination and Sharing
Dissemination channel	Website
Targeted audience (specified/objective analysis)	Regulators, Industry
Users access	Open access
Knowledge Characterization
3Rs relevance	Replacement, Reduction
Purpose	Regulatory testing, Documentation and information
Legislative framework	Cosmetics Regulation (EC) No 1223/2009, REACH Regulation (EC) No 1907/2006, CLP Regulation (EC) No 1272/2008, Biocidal Products Regulation (EC) No 528/2012, Plant Protection Products Regulation (EC) No 1107/2009
Technology/Tools	Alternative test methods (in vitro), Non-testing methods (in silico), Integrated approaches to testing and assessment (IATA)