Knowledge Source Identification
Knowledge source name DrugMatrix
Owner/Developer U.S. Department of Health and Human Services, National Toxicology Program
Abbreviated owner NTP
Country United States of America
Languages English
URL https://ntp.niehs.nih.gov/drugmatrix/index.html
Contact email drugmatrix@niehs.nih.gov
Description DrugMatrix is the scientific communities' largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, and environmental chemicals at both non-toxic and toxic doses. Following administration of these compounds in vivo, comprehensive studies of the effects of these compounds were carried out at multiple time points and in multiple target organs. These studies included extensive pharmacology, clinical chemistry, hematology, histology, body and organ weights, and clinical observations. Additionally, a curation team extracted all relevant information on the compounds from the literature, the Physicians' Desk Reference, package inserts, and other relevant sources. The heart of the DrugMatrix database is large-scale gene expression data generated by extracting RNA from the toxicologically relevant organs and tissues and applying these RNAs to the GE Codelinkā„¢ 10,000 gene rat array and more recently the Affymetrix whole genome 230 2.0 rat GeneChipĀ® array.
Knowledge Source Category
Category Information System
Sub categories Database
Knowledge Dissemination and Sharing
Dissemination channel Website
Targeted audience (specified/objective analysis) Scientists
Users access Open access
Knowledge Characterization
3Rs relevance Replacement, Reduction
Purpose Documentation and information
Technology/Tools Omics, High throughput screening, High content screening