Adverse Outcome Pathway Knowledge Base

Knowledge Source Identification
Knowledge source name	Adverse Outcome Pathway Knowledge Base
Abbreviated name	AOP-KB
Owner/Developer	The Organisation for Economic Co-operation and Development, European Commission, US Environmental Protection Agency, US Army Corps of Engineers - Engineering Research and Development Center
Abbreviated owner	OECD, EC, US EPA, ERDC
Country	France
Languages	English
URL	http://aopkb.org/
Description	To enable the scientific community, in one central location, to share, develop and discuss their AOP related knowledge, the OECD has launched a project to develop the "Adverse Outcome Pathway Knowledge Base" (AOP-KB). The AOP-KB allows all stakeholders to build AOPs by entering and then linking information about MIEs, KEs, AOs and Chemical Initiators. Knowing that pathway elements are not necessarily unique to a single AOP, value is added to existing knowledge by facilitating the re-use of MIE, KE and AO information in multiple AOPs, which prevents redundancy and make the collective knowledge about those entities available in all AOPs in which they appear.
Knowledge Source Category
Category	Information System
Sub categories	Knowledge-base
Knowledge Dissemination and Sharing
Dissemination channel	Website
Targeted audience (specified/objective analysis)	Scientists
Users access	Open access, User registration
Knowledge Characterization
3Rs relevance	Replacement, Reduction
Purpose	Fundamental studies, Toxicological and safety evaluation, Documentation and information